A systematic review published in Brain Medicine suggests that creatine monohydrate, a common muscle-building supplement, may serve as a beneficial add-on treatment for major depressive disorder. Researchers from the University of Ottawa analyzed five randomized controlled trials to evaluate the impact of creatine on mental health. The findings indicate that creatine may improve symptoms when combined with antidepressants like escitalopram or cognitive behavioral therapy. However, results were inconsistent, as studies involving teen girls and bipolar depression showed no significant benefits. Lead author Bassam Jeryous Fares emphasized that while the signal is interesting, more large-scale, well-controlled trials are required before changing clinical practices. Experts note that while creatine supports brain energy metabolism and is generally safe, it should be viewed as a potential complement to existing therapies rather than a standalone replacement for medication or psychotherapy.